Proteins are organic macro molecule found in all living
organism. They are polymers formed form condensation of amino acids joined by
peptide linkings and have the molecular weight of the chain that exceeds 10
000. Proteins contain the elements carbon, hydrogen, oxygen and nitrogen. Many
protein also contain sulphur and phosphorus.
AMINO ACIDS
An amino acid contains a basic amino group (-NH2)
an acidic carboxyl group (-COOH) a hydrogen atom and a R group are covalently
linked to the same carbon atom. The R group varies in different amino acids .
There are 20 amino acid which occur naturally in the protein of living
organism. The various combinations of different amino acid produce a various
protein. The amino acid act as buffer which help maintenance the environment of body internal fliud
because protein are amphoteric molecules. Each amino acid has its own specific
pH at which it will exist in zwitterion form. The isoelectric point of amino
acid is the pH that cause this electrical neutrality. Essential amino acid are
amino acid that cannot be synthesised in the body and which must be included in
the diet. Non essential amino acid can be synthesised from other amino acid in
the body provide there is adequte total dietery proteins.
PEPTIDES AND POLYPEPTIDES
The amino acid group is joined to the carboxyl group of
other amino acid by a peptide bond ina condensation reaction to form a
dipeptide. The bond linking the two amino acids is called peptide bond.
Succesive condensation of amino acid form a polypeptide chain. The proces
called polymerisation. A protein molecule consist of one or more polypeptides.
CLASSIFICATION OF PROTEINS
Some common methods used to group proteins are based on:
Levels of organisation – Primary, secondary, tertiary, and
quarternary structures.
Structures – fibrous and globular proteins.
Composition – simple and conjugated protein
Functions – structural, catalysis, signals, movement,
defense and storage.
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